Alzheimer's Disease

Advancing Alzheimer’s Research with High-Resolution MEA Technology

Alzheimer’s Disease is a progressive neurodegenerative disorder that causes cognitive decline, memory loss, and behavioral changes, profoundly affecting patients and their families. At VitroVo, we leverage over 20 years of expertise in Microelectrode Array (MEA) technology and iPSC-derived models to offer groundbreaking insights into Alzheimer’s pathology and drug discovery. Our cutting-edge electrophysiology assays provide a powerful platform for studying disease mechanisms, testing compounds, and accelerating the development of effective therapies.

VitroVo’s Innovative Approach to Alzheimer’s Disease Research

VitroVo’s MEA technology allows for high-resolution neural network analysis to study the dysfunctions that occur in Alzheimer’s. Our AI-powered analytics transform complex data into actionable insights, enabling researchers to make more informed decisions when evaluating compounds for cognitive disorders. By using iPSC-derived neurons and brain organoids, we offer highly relevant Alzheimer’s disease models that replicate the key features of the disease, such as amyloid plaque formation, tau tangles, and neuronal death.

Key Benefits of VitroVo’s Alzheimer’s Drug Discovery Platform

Accurate Disease Modeling:

Leverage iPSC-derived neurons and brain organoids to model amyloid-beta plaques, tau aggregation, and neurodegeneration, mimicking key aspects of Alzheimer’s disease.

High-Resolution MEA Analysis:

Our HD-MEA platform offers single-cell resolution to observe the functional changes in neuronal networks that occur in Alzheimer’s, providing deeper insights than traditional methods.

Predictive Drug Screening:

Use AI-driven analytics to evaluate drug candidates for neuroprotective effects, amyloid-beta reduction, and other disease-modifying outcomes, supporting faster and more cost-effective clinical trials.

How VitroVo’s Capabilities Drive Alzheimer’s Drug Discovery

VitroVo integrates advanced electrophysiology, neuroscience modeling, and AI analytics to revolutionize Alzheimer’s drug discovery. Our MEA assays enable precise monitoring of neural activity, synaptic function, and neuroplasticity, which are critical to understanding the progression of Alzheimer’s. By coupling AI with multi-parameter data, we provide actionable insights for early-stage drug development, increasing the likelihood of successful outcomes.

High-Throughput Screening:

Benefit from mid-throughput assays (24-well plates) to test compounds in Alzheimer’s models, obtaining snapshots of their effects on neuronal networks with precision.

Biomarker Discovery:

Analyze changes in calcium dynamics, gene expression (RNA-seq), and protein biomarkers (ELISA) to identify novel biomarkers for early Alzheimer’s diagnosis and treatment monitoring.

Enhanced Disease Understanding:

Use our multivariate analysis (e.g., PCA, UMAP) to study the complex interactions between amyloid, tau, and neuronal networks, providing a comprehensive view of disease progression.

Explore VitroVo’s Alzheimer’s Models and Services

VitroVo offers a range of customizable models and assay platforms for Alzheimer’s disease research:

hiPS-CNS Neurons (Glutamatergic, GABAergic, Dopaminergic):

Model Alzheimer’s disease through the dysfunction of various neuronal populations involved in memory and cognition.

Brain Organoids:

Recreate Alzheimer’s disease pathology in 3D models, capturing amyloid plaques, tau tangles, and neurodegeneration with unmatched biological relevance.

Neurodegenerative Disease Assays:

Assess drug efficacy, neurotoxicity, and synaptic activity to support Alzheimer’s research and the development of disease-modifying drugs.

VitroVo’s expertise in in-vitro electrophysiology, AI-powered analytics, and disease modeling provides a powerful platform for advancing Alzheimer’s Disease research and accelerating the development of effective therapies.

Contact us today to learn how our specialized assays can support your research in Alzheimer’s Disease drug discovery.

Assays

See assay examples below to find out how VitroVo can advance your Alzheimer’s Disease research