Developmental Neurotoxicity

Ensuring Safe Development with Advanced Neurotoxicity Testing

Developmental neurotoxicity (DNT) testing is critical in identifying compounds that may disrupt the growth, differentiation, and function of the nervous system, particularly in early stages of development. At VitroVo, our cutting-edge in-vitro electrophysiology assays, coupled with advanced analytics, provide unparalleled insights into DNT risks, helping you meet regulatory standards while minimizing clinical trial risks.

Why Developmental Neurotoxicity Profiling Matters

Understanding the potential neurotoxic effects of a compound during the development stage is crucial to:

• Safeguard vulnerable populations: Protect infants, children, and pregnant individuals from long-term neurodevelopmental harm.
• Meet regulatory compliance: Align your drug development process with OECD-compliant DNT guidelines to meet international safety standards.
• Avoid costly late-stage failures: Identify risks early to optimize compound safety and reduce the risk of developmental toxicity in clinical trials.

VitroVo’s Expertise in Developmental Neurotoxicity Testing

Comprehensive DNT Testing Using Advanced Platforms

Microelectrode Array (MEA) Technology:

• Analyze changes in neuronal network activity to identify neurotoxic effects.
• Record critical functional parameters, including firing rate, synchrony, and burst patterns, indicative of developmental disruption.

Advanced Analytics:

• Detect subtle, compound-induced changes in neuronal activity using OECD working group defined parameters.
• Perform multivariate analyses (e.g., PCA, UMAP) to identify patterns linked to developmental neurotoxicity.

Key Functional Parameters Assessed:

• Neurogenesis Impairment: Evaluate the effects on the proliferation and differentiation of neurons.
• Synaptic Plasticity and Network Formation: Monitor the development of functional neuronal circuits over time.
• Glial Cell Function: Assess the impact on supporting cells like astrocytes and microglia involved in healthy brain development.

Advanced DNT Models Tailored to Your Needs

VitroVo’s Cutting-Edge Models for DNT Testing:

• Human iPSC-Derived Cells: Assess neurodevelopmental effects in human-relevant systems, including neural precursor cells, glutamatergic, GABAergic neurons, and astrocytes.
• Co-Culture Systems: Evaluate neuron-glia interactions to detect broader developmental impacts.

Why VitroVo for Developmental Neurotoxicity Testing?

Unmatched Benefits of Partnering with VitroVo:

• Industry-Leading Expertise: Over two decades of experience in MEA technology and neurotoxicity profiling.
• Regulatory Compliance: Assays aligned with OECD DNT testing guidelines, ensuring results meet global standards.
• Comprehensive Data Integration: Combine electrophysiological data with molecular and imaging readouts for a complete understanding of developmental risks.
• Efficient and Cost-Effective Solutions: Accelerate the drug development process while reducing the need for costly and time-consuming in vivo studies.

Partner with VitroVo for Predictive DNT Safety Profiling

At VitroVo, we provide industry-leading expertise and state-of-the-art technologies to help you predict and mitigate developmental neurotoxicity risks. By integrating advanced assays and analytics, we ensure the success and safety of your therapeutic pipeline.

Contact Us:

Ready to take the next step in your DNT testing? Reach out to our experts today to discuss your project and learn how VitroVo can support your safety profiling needs.

Assays

See assay examples below to find out how VitroVo can advance your DNT research